Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing
2024-05-24
USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy
2024-04-10
UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
2024-03-21
Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability
2024-03-16
Ptip safeguards the epigenetic control of skeletal stem cell quiescence and potency in skeletogenesis
2024-02-29
Fast and sensitive CRISPR detection by minimized interference of target amplification
2024-02-08
Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115
2024-01-24
EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses
2024-01-22
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease
2024-01-02
m(6)A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3
2023-12-21
A novel antidiuretic hormone governs tumour-induced renal dysfunction
2023-12-06
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
2023-12-04
Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
2023-12-01
UVRAG cooperates with cargo receptors to assemble the ER-phagy site
2023-12-01
HILPS, a long noncoding RNA essential for global oxygen sensing in humans
2023-11-24
PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity
