飞速体育cba

教育经历

2002-2006  华中师范大学，学士

2006-2012  中国科学院生物物理研究所，博士

工作经历与任职

2013-2018  University of North Carolina at Chapel Hill, NC, US，Postdoc

2018-2020  University of North Carolina at Chapel Hill, NC, US，Research Associate

2020-至今 飞速体育cba，教授

所获研究资助

武汉市“武汉英才”，2021

湖北省“百人计划”创新人才，2021

科技部“干细胞研究与器官修复”重点专项（青年科学家项目，主持，2022-2026）

国家自然科学基金重大研究计划（培育项目）（主持，2021-2023）

国家自然科学基金面上项目（主持，2021-2024、2025-2029）

Career Development Award, American Heart Association （主持，2018-2020）

研究领域及研究成果

        成年心脏几乎不具备再生能力，本实验室致力于通过细胞重编程技术破解心脏再生的核心机制。我们以心肌细胞命运重塑为主线，围绕衰老、代谢、RNA 加工等多维调控机制系统解析成纤维细胞向有功能心肌细胞转变的关键分子网络。实验室通过多组学、细胞与分子生物学以及多种体内转化模型，揭示了一系列调控心肌细胞命运转化的核心因子，并推动重编程心脏再生策略向临床转化迈进。我们的目标是为心血管再生医学提供系统性的理论基础和面向未来的创新治疗方向。

代表性论文

1. Liu M, Yu Z, He Z, Zhou Z, Liu J, Liu L, Wu X, Li J, Huang Y, Xiang L, Kong X, Lu Z, Wang L. Blocking nuclear receptor Nr4a3 unlocks the senescence barrier to promote direct cardiac reprogramming. Science Advances. 2025 Nov 14;11(46):eadz4847.

2. Jia, Z., Xiang, L., Yu, Z., Wang, L., Fang, J., Liu, M., Wu, X., Lu, Z., and Wang, L. Enhanced Fatty Acid Oxidation via SCD1 Downregulation Fuels Cardiac Reprogramming. Molecular Therapy. 2025. 10.1016/j.ymthe.2025.02.034.

3. Li J, Cai H, Chen Y, Pi R, Xiang L, Lu Z, Zhou Y, Wang L. Long noncoding RNA LncBAR enhances BRG1 protein to promote cardiomyocyte cell cycle progression and cardiac repair. NPJ Regenerative medicine. 2025 Nov 17;10(1):52.

4. Xiang L, Jia Z, Yu Z, Wang L, Cai H, Zhang T, Lu Z, Wang L. Beclin1 deficiency unlocks cardiac lineage commitment through convergent Wnt and BMP signaling activation. Stem Cell Research & Therapy. 2025 Nov 13;16(1):636.

5. Liu J, Feng J, Zhao J, Kong X, Yu Z, Huang Y, He Z, Liu M, Liu Z, Lu Z, Wang L. TFAP4 exacerbates pathological cardiac fibrosis by modulating mechanotransduction. Cell Insight. 2025 Jun 2;4(4):100256.

6. Song Y*, Wang L*, Wang H, Ma H, Xu J, Liu J, Qian L. Decoding aging in the heart via single cell dual omics of non-cardiomyocytes. iScience, 2024 Nov 28;27(12):111469. * Equal contribution.

7. Huang, P., Xu, J., Keepers, B., Xie, Y., Near, D., Xu, Y., Hua, J.R., Spurlock, B., Ricketts, S., Liu, J., Wang, L.#, Qian, L#. Direct cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression. Molecular Therapy Nucleic Acids, 2024.35, 102390.  #co-correspondence.

8. Wang L*, Yang Y*, Ma H, Xie Y, Xu J, Near, D., Wang, H., Garbutt T, Liu J, Qian L. Single Cell Dual-Omics Reveals the Transcriptomic and Epigenomic Diversity of Cardiac Non-myocytes. Cardiovascular Research, 2021, cvab134.

9. Wang L, Ma H, Huang P, Xie Y, Near D, Wang H, Xu J, Yang Y, Xu Y, Garbutt T, Zhou Y, Liu Z, Yin C, Bressan M, Taylor JM, Liu J, Qian L. Down-regulation of Beclin1 promotes direct cardiac reprogramming. Science Translational Medicine, 2020,12;566

10. Liu Z*., Wang L.*, Welch J.*, Ma H., Zhou Y., Vaseghi H.R., Yu S., Wall J.B., Alimohamadi S., Zheng M., Yin C., Shen W., Prins J., Liu J.and Qian L. Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte. Nature, 2017,551(7678):100-104.

11. Wang L. *, Liu Z. *, Yin C., Asfour H., Chen O., Li Y., Bursac N., Liu J. and Qian L. Stoichiometry of Gata4, Mef2c and Tbx5 influences the efficiency and quality of iCM reprogramming. Circulation Research. 2015, 116, 237-244. * Equal contribution. (Editor’s Pick; highlighted on cover; Previewed in Muraoka et al., Circ Res, 116:216-218.)

论著

12. Wang L., Liu J. and Qian L. (2017) In vivo Lineage Reprogramming of Fibroblasts to Cardiomyocytes for Heart Regeneration. In:In Vivo Reprogramming in Regenerative Medicine (Stem Cell Biology and Regenerative Medicine)(Yilmazer ed) Springer International Publishing AG. p45-63.

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