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Quadruple pegRNA enables programmable and efficient large genomic insertion

TM9SF3 is a Golgi-resident ATG8-binding protein essential for Golgi selective autophagy

CaMK modulates sensory neural activity to control longevity and proteostasis

Chemical-based epigenetic reprogramming to advance pluripotency and totipotency

Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis

TOPO-seq reveals DNA topology-induced off-target activity by Cas9 and base editors

An epitranscriptomic program maintains skeletal stem cell quiescence via a METTL3-FEM1B-GLI1 axis

KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31