飞速体育cba

教育经历

2003-2007  湖南大学 生命科学与技术学院 学士

2007-2013  清华大学 生命科学学院 博士

工作经历与任职

2013-2015  清华大学 博士后

2015-2019  美国加州大学圣地亚哥分校 博士后及助理项目科学家

2020-至今  飞速体育cba/免疫与代谢前沿科学中心 教授、博导；彩9中南医院 特聘教授

所获研究资助

海外高层次人才计划A类（2021-2023，主持）

国家科技部重点研发专项（2021-2025，课题组长）

国家科技重大专项（2025-2028，课题组长）

国家科技部重点研发专项（2021-2024，骨干）

国家自然科学基金重大研究计划培育项目（2026-2028，主持）

国家自然科学基金面上项目（2021-2024，主持）

国家自然科学基金面上项目（2024-2027，主持）

国家自然科学基金青年科学基金项目 （2014-2016，主持）

彩9重点交叉团队建设项目（2025，主持）

彩9“双一流”建设专项人才启动经费（2020-2022，主持）

研究领域

内质网/高尔基体自噬与疾病发生：选择性自噬通过受体分子将特定的蛋白或细胞器靶向到自噬小体进行降解，以维持细胞稳态。它与多种疾病（如神经退行性疾病、癌症）的发生关系密切。内质网和高尔基体作为细胞内的重要细胞器，其选择性自噬降解机制受到了高度关注，但目前对其调控机制及生理病理功能还很不清楚。研究策略：利用酿酒酵母全基因组敲除文库和细胞CRISPR敲除文库进行大规模遗传筛选，鉴定了新的内质网自噬及高尔基体自噬因子；跨模型（酿酒酵母、哺乳动物细胞、果蝇和小鼠）开展机制研究；并解析其在多种疾病（如阿尔茨海默症和癌症）发生中的作用。

代表性论文

[1] Yixian Cui, Smriti Parashar, Muhammad Zahoor, Patrick G. Needham, Muriel Mari, Ming Zhu, Shuliang Chen, Hsuan-Chung Ho, Fulvio Reggiori, Hesso Farhan, Jeffrey L. Brodsky, and Susan Ferro-Novick*. A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation. Science, 365, 53–60, 2019

[2] Jiejie Yang, Yang Dong, Jiaxin Xu, Xuehong Qian, Yang Cai, Yanjun Chen, Pei Zhang, Ding Gao, Zongqiang Cui, Yixian Cui*. TM9SF3 is a Golgi-resident ATG8-binding protein essential for Golgi selective autophagy. Developmental Cell, S1534-5807(25)00372-7, 2025

[3] Yang Dong#, Sufang Tian#, Xueying Peng, Ping Wang, Xuehong Qian, Chenxi Xie，Rongfu Tu, Xinghuan Wang*, Yixian Cui*. CCPG1-mediated reticulophagy promotes tumorigenesis and cisplatin resistance in bladder cancer. Autophagy, 2025

[4] Xueying Peng and Yixian Cui*. PDZD8 orchestrates synaptic remodeling through autophagy. Trends in Neurosciences, 2025

[5] Jiejie Yang and Yixian Cui*. TM9SF3 is a mammalian Golgiphagy receptor that safeguards Golgi integrity and glycosylation fidelity. Autophagy, 2025

[6] Wenqing Mou, Yinglu Tang, Yunpeng Huang, Zhihao Wu*, Yixian Cui*. Upregulation of neuronal ER-phagy improves organismal ?tness and alleviates APP toxicity. Cell Reports, 43, 114255, 2024

[7] Wenqing Mou, Yixian Cui*. Enhancing neuronal reticulophagy: a strategy for combating aging and APP toxicity. Autophagy, 2024

[8] Xuehong Qian, Lingang He, Jiejie Yang, Jiajia Sun, Xueying Peng, Yuting Zhang, Yizhou Mao, Ying Zhang and Yixian Cui*. UVRAG cooperates with cargo receptors to assemble the ER-phagy site. The EMBO Journal, e13625, 2023

[9] Xuehong Qian, Jiajia Sun and Yixian Cui*. UVRAG: orchestrating the initiation of reticulophagy. Autophagy, 2023

[10] Lingang He, Xuehong Qian, Yixian Cui*. Advances in ER-phagy and its diseases relevance. Cells, 10(9):2328, 2021

[11] Yixian Cui, Smriti Parashar, and Susan Ferro-Novick*. A new role for a COPII cargo adaptor in autophagy. Autophagy, 2020

[12] Shuliang Chen, Muriel Mari, Smriti Parashar, Dongmei Liu, Yixian Cui, Fulvio Reggiori, Peter J. Novick*, Susan Ferro-Novick*. Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy. Proc Natl Acad Sci U S A, 117(31), 18530-18539, 2020

[13] Shuliang Chen, Yixian Cui, Smriti Parashar, Peter J. Novick*, and Susan Ferro-Novick*. ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network. Proc Natl Acad Sci U S A, 115(27), E6237-E6244, 2018

[14] Yixian Cui^#, * Shanke Zhao^#, Xudong Wang, Bing Zhou*. A novel Drosophila mitochondrial carrier protein acts as a Mg²⁺ exporter in fine-tuning mitochondrial Mg²⁺ homeostasis. Biochimica et Biophysica Acta (BBA) –Molecular Cell Research, 1863, 30–39, 2016

[15] Yixian Cui^#, *, Shanke Zhao#, Juan Wang, Xudong Wang, Bingquan Gao, Qiangwang Fan, Fei Sun, Bing Zhou*. A novel mitochondrial carrier protein Mme1 acts as a yeast mitochondrial magnesium exporter. Biochimica et Biophysica Acta (BBA) –Molecular Cell Research, 1853, 724–732, 2015

[16] Yixian Cui, Shanke Zhao, Zhihao Wu, Pinghua Dai, Bing Zhou*. Mitochondrial release of the NADH dehydrogenase Ndi1 induces apoptosis in yeast. Molecular Biology of the Cell, 23(22), 4373-4382, 2012