飞速体育cba

学习经历

2011-2015 北京大学生命科学学院，学士

2015-2020 英国牛津大学Nuffield Department of Medicine，博士

工作经历与任职

2020-2020 英国牛津大学Nuffield Department of Women's & Reproductive Health，博士后

2021-2023 英国牛津大学MRC Weatherall Institute of Molecular Medicine，博士后

2023至今 飞速体育cba，教授

研究方向

胚胎发育和癌症有着密不可分的联系。癌症的表型和表观遗传特征往往重现了胚胎期的器官发育过程，癌症的发生发展亦会劫持胚胎发育期的调控机制。我们课题组的工作涵盖“湿实验”、“干实验”两方面，应用前沿单细胞空间多组学和人工智能方法，以基因调控复杂网络为着手点，全面系统地去研究发育与疾病中的细胞状态转变及其调控机制。我们课题组旨在全基因组层面和单细胞分辨率解析发育过程中的细胞命运决定与组织器官形成机制，并揭示这些发育程序在癌症等疾病中的异常重启与重塑。课题组主页：https://zhiyuan-hu-lab.github.io

课题组热忱欢迎有兴趣的科研助理、学生和博士后加入我们的团队！

获奖与荣誉

2022 Junior Research Fellowship, Wolfson College, University of Oxford

2021 NIHR Oxford Biomedical Research Centre Small Grants in Health Sciences

2020 WHG Public Engagement Seed Award, University of Oxford

2019 AACR-Margaret Foti Scholar-in-Training Award, American Association for Cancer Research

代表性论文

1. W. Wang^?, Z. Hu^?, P. Weiler^?, S. Mayes, M. Lange, D. M. Fountain, J. O. Haug, J. Wang, Z. Xue, T. Sauka-Spengler*, F. J. Theis*. RegVelo: gene-regulatory-informed dynamics of single cells. Cell 189(12), 3773–3800.e44 (2026).

2. C. Ding^?, Q. Zhang^?, J. Wang, Y. Xu, T. Huang, Y. Du, J. Zhang, X. Zhou*, Y. Liu*, Z. Hu*. FINE-EM-seq: a rapid isothermal amplification method enabling comprehensive methylome profiling of zebrafish early embryos. Cell Insight 5, 100324 (2026).

3. T.-T. Ji^?, N.-B. Xie^?, Y. Zhu^?, J. Xiong, Y.-H. Gu, X. Guo, S. Zhang, F.-Y. Gang, Z. Hu*, Y. Liu*, B.-F. Yuan*. Genome-wide single-nucleotide resolution mapping of DNA damage by dual enzyme cleavage-assisted sequencing. Analytical Chemistry 98(19), 14349–14360 (2026).

4. B. Lin^?, Z. Jiao^?, S. Dong^?, W. Yan, J. Jiang, Y. Du, X. Weng*, H. Wang*, Z. Hu*, Y. Liu*, X. Zhou*. Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features. Nature Communications 16, 8084 (2025).

5. Z. Hu, A. Ahmed*, C. Yau*. CIDER: an interpretable meta-clustering framework for single-cell RNA- seq data integration and evaluation. Genome Biology 22, 337 (2021).

6. Z. Hu?, P. Cunnea?, Z. Zhong, H. Lu, O. Osagie, L. Campo, M. Artibani, K. Nixon, J. Ploski, L. Santana Gonzalez, A. Alsaadi, N. Wietek, S. Damato, S. Dhar, S. P. Blagden, C. Yau, J. Hester, A. Albukhari, E. O. Aboagye, C. Fotopoulou*, A. A. Ahmed*. The Oxford Classic links epithelial-mesenchymal transition to immunosuppression in poor prognosis ovarian cancers. Clinical Cancer Research (2021).

7. Y. Liu^?, Z. Hu^?, J. Cheng, P. Siejka-Zielinska, J. Chen, M. Inoue, A. A. Ahmed, C.-X. Song. Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution. Nature Communications 12, 618 (2021).

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