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Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis

TOPO-seq reveals DNA topology-induced off-target activity by Cas9 and base editors

Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining

An epitranscriptomic program maintains skeletal stem cell quiescence via a METTL3-FEM1B-GLI1 axis

KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31

Diverse microtubule-binding repeats regulate TPX2 activities at distinct locations within the spindle

The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to govern anti-tumor immunity

A noncoding variant confers pancreatic differentiation defect and contributes to diabetes susceptibility by recruiting RXRA